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Aberrant elemental composition of otoconia in the dancer mouse mutant with a semidominant gene causing a
M Anniko1, B I Wenngren, R Wróblewski
1Department of Oto-Rhino-Laryngology, Umeå University Hospital, Sweden.
Abstract:
The elemental composition of otoconia from Jerker and Dancer mouse mutants was analysed in both maculae. A normal elemental content was found in otoconia from Jerker mutants, whereas in the Dancer mutant a large number of otoconia from both maculae contained very high concentrations of phosphorus. In these otoconia, the phosphorus calcium ratio was approximately 1:8, in Jerker (and normal) otoconia approximately 1:150-200. However, otoconia from Dancer mutants occurred with also a normal elemental composition. The increasing content of phosphorus in otoconia may possibly indicate an early onset of aging, i.e. corresponding to a phosphatization process as described in aging human otoconia.