Risk factor for diabetes mellitus in pediatric chronic pancreatitis patients

Area of Science:

• Gastroenterology
• Endocrinology
• Pediatrics

Background:

• Chronic pancreatitis (CP) is a significant health concern in pediatric populations.
• The co-occurrence of diabetes mellitus (DM) in pediatric CP patients presents unique challenges.
• Understanding DM incidence and risk factors in this demographic is crucial for effective management.

Purpose of the Study:

• To determine the incidence of diabetes mellitus (DM) in pediatric patients diagnosed with chronic pancreatitis (CP).
• To identify specific risk factors associated with the development of DM in this pediatric CP cohort.
• To compare DM incidence and risk factors between pediatric and adult CP patients.

Main Methods:

• Retrospective cohort study of 2153 CP patients from January 2000 to December 2013.
• Patients were categorized into pediatric (<18 years) and adult groups based on age at CP onset.
• Analysis included cumulative DM rates and identification of risk factors such as age at onset, smoking, BMI, and etiology.

Main Results:

• 13.1% of the CP cohort were pediatric patients.
• Diabetes mellitus (DM) was detected in 13.1% of pediatric CP patients, compared to 31.0% in adults.
• Identified risk factors for DM in pediatric CP included age at onset, smoking history, body mass index (BMI), and etiology of CP.

Conclusions:

• Diabetes mellitus (DM) affects a notable proportion of pediatric patients with chronic pancreatitis (CP).
• Early age at CP onset, smoking, elevated BMI, and specific etiologies are significant risk factors for DM development.
• Frequent monitoring and lifestyle modifications are recommended for high-risk pediatric CP patients to mitigate DM development.