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Advances in gastrointestinal vascular bleeding disorders: Successful sirolimus treatment in colonic angioectasia
Qi Sun1, Xiao-Ying Wang1,2, Dong-Hao Li1
1Department of Gastroenterology, Air Force Medical Center, Beijing 100142, China.
Insights
Research on gastrointestinal vascular bleeding disorders shows a trend towards pharmacological treatments, like sirolimus for angiodysplasia, improving patient outcomes. This shift offers new management strategies for these challenging conditions.
Area of Science:
- Gastroenterology and Hepatology
- Vascular Medicine
- Bibliometrics and Research Trends
Background:
- Gastrointestinal (GI) vascular bleeding disorders present complex clinical challenges with varied treatment responses.
- Optimal management strategies for these conditions are still evolving, necessitating ongoing research.
- Existing diagnostic and therapeutic techniques require further refinement.
Purpose of the Study:
- To analyze research trends and clinical advancements in GI vascular bleeding disorders.
- To identify key themes and therapeutic progress in the field.
- To evaluate the evolving landscape of GI vascular bleeding disorder management.
Main Methods:
- Bibliometric analysis of 470 scholarly articles (2000-2024) from the Web of Science Core Collection.
- Identification of publication trends, high-frequency keywords, and leading research institutions.
- Case study illustrating sirolimus efficacy in managing refractory colonic angioectasia.
Main Results:
- The United States led publications, with significant international collaborations.
- A notable trend shows a shift from endoscopic interventions to pharmacological therapies.
- Sirolimus demonstrated success in treating colonic angioectasia; keywords like "angiodysplasia," "colon," and "management" were prominent, with growing interest in "thalidomide."
Conclusions:
- Bibliometric analysis combined with clinical insights reveals a paradigm shift towards pharmacological management.
- This approach aims to enhance patient outcomes in GI vascular bleeding disorders.
- The findings underscore the growing importance of drug-based therapies in managing these conditions.
Background:
Gastrointestinal (GI) vascular bleeding disorders pose significant clinical challenges due to their complex pathogenesis and varied treatment responses. Despite advancements in diagnostic and therapeutic techniques, optimal management strategies remain elusive, necessitating further research.
Aim:
To assess research trends and clinical advancements in GI vascular bleeding disorders, highlighting key themes and therapeutic progress.
Methods:
A bibliometric analysis was conducted using the Web of Science Core Collection database, reviewing publications from 2000 to 2024 to identify trends, high-frequency keywords, and key contributions from leading research institutions. In addition, a case study highlighted the effective application of sirolimus in managing colonic angioectasia in a patient with recurrent GI bleeding who had not responded to previous treatments.
Results:
The analysis reviewed 470 scholarly articles from 203 countries, involving 2817 authors across 1502 institutions. The United States led in publication contributions, with strong collaborations with countries like China, England, and Germany. A significant trend was observed in the shift from traditional endoscopic interventions to pharmacological therapies, particularly highlighting the successful use of sirolimus in treating colonic angioectasia. High-frequency keywords such as "angiodysplasia", "colon", and "management" were identified, indicating key research themes. The study also noted a growing interest in drug therapies, as evidenced by the increasing prominence of keywords like "thalidomide" since 2018.
Conclusion:
This study links bibliometric analysis and clinical insights, highlighting the shift to pharmacological management in GI vascular bleeding disorders to improve patient outcomes.
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