Cross-linked chitosan microparticles preparation by modified three fluid nozzle spray drying approach

Area of Science:

• Biomaterials Science
• Polymer Chemistry
• Drug Delivery Systems

Background:

• Chitosan is widely studied for drug delivery due to its biocompatibility and biodegradability.
• Developing effective delivery systems for bioactive molecules like quercetin and ferulic acid is crucial for health benefits.

Purpose of the Study:

• To fabricate core-shell structured chitosan microparticles encapsulating quercetin and ferulic acid.
• To evaluate the physicochemical properties, compatibility, and antioxidant activity of the developed microparticles.
• To assess the sustained release profile of the dual bioactive molecules.

Main Methods:

• Fabrication of core-shell chitosan microparticles using a three-fluid nozzle (3-FN) spray drying technique.
• Crosslinking of microparticles with tripolyphosphate and sodium alginate.
• Characterization using microscopy, thermal analysis, and compatibility studies.
• Assessment of free radical scavenging activity and in vitro release studies.

Main Results:

• Spherical, core-shell structured microparticles were successfully fabricated.
• Confirmation of crosslinking, compatibility, and successful encapsulation of bioactive molecules.
• Sustained release of 85-88% for dual bioactive molecules over 24 hours.
• Enhanced free radical scavenging potency compared to controls.

Conclusions:

• The developed cross-linked, core-shell chitosan microparticles are a promising dual delivery system.
• The system effectively encapsulates bioactive molecules with synergistic antioxidant activity.
• This approach offers a viable strategy for enhancing the therapeutic potential of quercetin and ferulic acid.