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Active-electrode biosensor of SnO2 nanowire for cyclodextrin detection from microbial enzyme
Cleber A Amorim1, Kate C Blanco2, Ivani M Costa3
1Universidade Estadual Paulista, Faculdade de Ciências e Engenharia de Tupã, Tupã, Av. Domingos da Costa Lopes, 780 Jardim Itaipu, Tupã, SP, Brazil.
Nanotechnology
|November 27, 2019
Summary
This study introduces a novel SnO2 nanowire biosensor for detecting cyclodextrin (CD). The biosensor leverages changes in electrical conductivity upon CD adsorption, offering a new method for CD detection.
Area of Science:
- Materials Science
- Nanotechnology
- Biochemistry
Background:
- Cyclodextrins (CDs) are conical compounds vital for complexing hydrophobic substances in the food and pharmaceutical industries.
- CDs are produced from starch via microbial enzyme activity.
- Detection of CDs is crucial for various industrial applications.
Purpose of the Study:
- To develop and evaluate an active-electrode biosensor utilizing tin oxide (SnO2) nanowires for cyclodextrin (CD) detection.
- To investigate the interaction between CDs and SnO2 nanowires and its effect on electrical properties.
Main Methods:
- SnO2 nanowires were synthesized on an active electrode using the Vapor-Liquid-Solid (VLS) method.
- Electrical conductivity measurements were performed at varying CD concentrations.
- A model was developed to describe glucose adsorption effects on nanowire conductivity.
Main Results:
- The study presents experimental results demonstrating changes in electrical conductivity of SnO2 nanowires in response to different CD concentrations.
- The binding of glucose units' hydroxyl groups to nanowire interface states was observed to alter conductivity.
- A model correlating glucose adsorption with electrical property changes was established.
Conclusions:
- The SnO2 nanowire-based biosensor shows potential for detecting cyclodextrin.
- The adsorption mechanism involving glucose hydroxyl groups and nanowire interface states is key to the sensing principle.
- Further observations address the general applicability of this nanowire-based biosensing approach for CD detection.
