Related Experiment Video
Updated: Jan 3, 2026
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
13.7K
[Geriatric specificities of prostate cancer]
P Mongiat-Artus1, E Paillaud2, P Caillet3
1Service d'urologie et unité de chirurgie et d'anesthésie ambulatoires, université Paris Diderot - université de Paris, Inserm UMR_S1165, hôpital Saint-Louis, Assistance publique-Hôpitaux de Paris, 1, avenue Claude-Vellefaux, 75010 Paris, France.
Summary
Prostate cancer (PCa) is common in the elderly, often diagnosed at later stages. Following current guidelines for diagnosis and treatment can improve outcomes for older patients.
Area of Science:
- Geriatric oncology
- Epidemiology of cancer
- Prostate cancer research
Background:
- Prostate cancer (PCa) is the most common cancer in the elderly.
- Disease-specific mortality increases with age.
- Older patients are more frequently diagnosed with higher-grade and later-stage PCa.
Purpose of the Study:
- To outline the epidemiology and natural history of prostate cancer in elderly individuals.
- To suggest geriatric evaluation adaptations for PCa.
- To review therapeutic options for elderly patients with PCa.
Main Methods:
- Bibliographic research conducted on Medline and Embase databases.
- Searched websites of scientific societies in geriatrics and the National Cancer Institute.
- Utilized keywords: elderly, geriatrics, prostate cancer, diagnosis, treatment.
Main Results:
- Median age at PCa diagnosis is 69; mortality increases with age.
- Older patients present with higher grade/stage PCa and receive less curative treatment.
- Geriatric assessment is recommended, but cognitive disorder screening is debated; no prospective trials exist for elderly PCa patients.
Conclusions:
- Prostate cancer management in the elderly should adhere to current diagnostic and treatment guidelines.
- Adherence to guidelines can prevent late diagnoses and undertreatment in this population.
Related Concept Videos
01:20Disorders of the Male Reproductive System
3.9K
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
3.9K
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
158
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
158
01:15Drug Dosing: Geriatric Patients
189
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
189
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
205
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
205
01:00Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
175
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
175
01:21Nursing Assessment of the Genitourinary System I: Health History
331
The genitourinary system is critical to maintaining fluid balance, waste elimination, and reproductive function. Nurses play a vital role in assessing this system, beginning with a thorough health history. This process involves gathering patient information, identifying risk factors, and recognizing symptoms of genitourinary disorders. Early detection is vital for timely interventions and management.1. Gathering Patient InformationA complete health history includes the patient’s personal,...
331