Leptin and reproductive dysfunction in obese men
Fayez A Almabhouh1, Amir Hafidz Md Mokhtar1, Ifrah Alam Malik1
1Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Malaysia.
Andrologia
|November 28, 2019
Summary
Obese men often experience infertility due to issues like low sperm concentration and abnormal morphology. Elevated leptin levels, a hormone influenced by body fat, may be a key factor linking obesity to male reproductive dysfunction.
Area of Science:
- Reproductive Endocrinology
- Obesity Medicine
- Sperm Biology
Background:
- Obesity is linked to increased infertility prevalence in men.
- Obese men exhibit reduced sperm concentration, abnormal morphology, increased DNA fragmentation, and oxidative stress.
- Serum leptin levels correlate positively with body fat percentage.
Purpose of the Study:
- To review findings on sperm function in obese, infertile men.
- To examine animal studies on leptin treatment and reproductive function.
- To discuss leptin's potential role in male infertility associated with obesity.
Main Methods:
- Review of human studies on sperm parameters in obese men.
- Analysis of experimental animal studies involving leptin administration.
- Correlation analysis of leptin levels, body fat, and reproductive health indicators.
Main Results:
- Obese men show impaired sperm parameters, mirroring effects seen in leptin-treated animals.
- Elevated serum leptin levels are common in obese men.
- Leptin, while essential for reproduction, may negatively impact male fertility in excess.
Conclusions:
- Leptin is a potential mediator linking obesity to male infertility.
- High circulating leptin levels from adipose tissue may contribute to reproductive dysfunction in obese men.
- Further research is warranted to elucidate the precise mechanisms of leptin's impact on male reproductive health.
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