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Related Experiment Video

Updated: Jan 3, 2026

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Baroreflex activation therapy systems: current status and future prospects.

Gino Seravalle1, Raffaella Dell'Oro2, Guido Grassi2

  • 1Cardiology Department, IRCCS Istituto Auxologico Italiano, Milano, Italy.

Expert Review of Medical Devices
|November 28, 2019
PubMed
Summary
This summary is machine-generated.

Non-pharmacological approaches using device-based therapies can effectively lower blood pressure in resistant hypertension by stimulating carotid baroreceptors and modulating adrenergic tone.

Keywords:
Adrenergic nervous systembaroreceptorbaroreflex stimulationcardiovascular diseasesendovascular systemreflex mechanismresistant hypertensionsympathetic nerve activity

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Area of Science:

  • Cardiology
  • Nephrology
  • Neurology

Background:

  • Resistant hypertension involves hyperadrenergic tone and neurohumoral activation, often inadequately controlled by drug therapies.
  • Non-pharmacological interventions are crucial for managing resistant hypertension.
  • Stimulating carotid baroreceptors and modulating adrenergic tone are hypothesized to lower blood pressure.

Purpose of the Study:

  • To review the safety and efficacy of device-based therapies for resistant hypertension.
  • To discuss research on carotid baroreceptor stimulation and adrenergic tone modulation.

Main Methods:

  • Review of several studies and clinical trials evaluating device-based therapies.
  • Focus on research conducted in subjects with resistant hypertension.

Main Results:

  • Device-based therapies, specifically baroreflex activation therapy and endovascular baroreflex amplification, demonstrate safety and efficacy.
  • Carotid baroreceptor stimulation significantly reduces blood pressure and adrenergic tone.
  • Both systems have limitations, with potential for upgrades to improve side effect profiles.

Conclusions:

  • Device-based therapies offer a viable non-pharmacological approach for resistant hypertension.
  • Potential for wider application in other conditions with hyperadrenergic tone and neurohumoral activation.