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TAM receptors, Phosphatidylserine, inflammation, and Cancer

Tal Burstyn-Cohen1, Avi Maimon2

  • 1Institute for Dental Sciences, Faculty of Dental Medicine, The Hebrew University-Hadassah, Jerusalem, Israel. talbu@ekmd.huji.ac.il.

Cell Communication and Signaling : CCS
|November 29, 2019
PubMed

Insights

Phosphatidylserine (PtdSer) is crucial for activating TAM receptor tyrosine kinases (TYRO3, AXL, MERTK) in inflammation and cancer. This review explores PtdSer

Area of Science:

  • Cell biology
  • Immunology
  • Oncology

Background:

  • Phosphatidylserine (PtdSer) has diverse biological roles.
  • The TAM family of receptor tyrosine kinases (TYRO3, AXL, MERTK) are activated by ligands Protein S (PROS1) and growth-arrest-specific 6 (GAS6).
  • PtdSer acts as a cofactor for TAM receptor activation.

Purpose of the Study:

  • To review the role of PtdSer as a cofactor in TAM receptor tyrosine kinase signaling.
  • To highlight PtdSer's involvement in inflammation and cancer through TAM signaling.
  • To discuss the implications of PtdSer in the tumor microenvironment (TME).

Main Methods:

  • Literature review focusing on PtdSer and TAM signaling.
  • Analysis of PtdSer's role in receptor activation and biological functions.
  • Examination of PtdSer's impact on inflammation and cancer within the TME.

Main Results:

  • PtdSer binding to TAMs is essential for their activation.
  • PtdSer broadens its biological repertoire through TAM-mediated functions.
  • TAM signaling, influenced by PtdSer, plays roles in tissue homeostasis, inflammation, and cancer.

Conclusions:

  • PtdSer is a critical component for maximal TAM signaling.
  • PtdSer significantly impacts immune cells, inflammation, and tumor biology via TAM pathways.
  • Understanding PtdSer's role in TAM signaling offers insights into disease mechanisms and potential therapeutic strategies.
Keywords:
CancerGAS6InflammationPROS1PhosphatidylserineProtein SPtdSerTAM receptors

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