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Vaccine-preventable meningitis in French children with incorrect vaccination status from 2011 to 2013

J Truong1, C Levy2, S Prot-Labarthe3

  • 1Service de Pédiatrie Générale, CHU Robert Debré (AP-HP), 48, boulevard Sérurier, 75019 Paris, France.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|November 29, 2019
PubMed

Insights

In France, 48 children experienced vaccine-preventable meningitis or purpura fulminans due to incorrect vaccination status between 2011-2013. These cases, including three deaths, highlight the importance of adhering to the French immunization schedule.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Immunology

Background:

  • Pediatric meningitis and purpura fulminans are severe conditions that can be prevented by vaccination.
  • Vaccination status plays a critical role in preventing these infections.

Purpose of the Study:

  • To determine the incidence of pediatric meningitis or purpura fulminans linked to incomplete vaccination in France from 2011 to 2013.
  • To identify the causative pathogens in these vaccine-preventable cases.

Main Methods:

  • Retrospective analysis of pediatric cases of meningitis or purpura fulminans in France between 2011 and 2013.
  • Review of vaccination records for affected children to assess vaccination status.

Main Results:

  • 48 children presented with vaccine-preventable meningitis or purpura fulminans.
  • Neisseria meningitidis group C (54.2%), Streptococcus pneumoniae (39.6%), and Haemophilus influenzae type b (6.3%) were the primary pathogens.
  • 35 children (72.9%) had not received the relevant vaccine.

Conclusions:

  • A significant number of pediatric meningitis or purpura fulminans cases in France during the study period were associated with suboptimal vaccination.
  • Adherence to the French immunization schedule could have potentially prevented these 48 cases, including three deaths.

Keywords:
Bacterial meningitisChildrenVaccine

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