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Updated: Jan 3, 2026

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
Published on: December 23, 2016
Polyamine transport system-targeted nanometric micelles assembled from epipodophyllotoxin-amphiphiles
Julien Alliot1, Ioanna Theodorou, Frédéric Ducongé
1Service de Chimie Bioorganique et de Marquage (SCBM), CEA, Université Paris-Saclay, 91191 Gif-sur-Yvette, France. edmond.gravel@cea.fr eric.doris@cea.fr.
Abstract:
Micelle-forming amphiphilic drug conjugates were synthesized starting from a biologically active epipodophyllotoxin derivative which was covalently inserted in between a hydrophilic targeting spermine unit, and a hydrophobic stearyl chain. The amphiphilic drug conjugates were further assembled into the corresponding micelles and evaluated in vitro for the active targeting of tumor cells overexpressing the polyamine transport system.

