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Related Concept Videos

Autophagy01:27

Autophagy

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Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
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Autophagic Cell Death01:18

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Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
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Delivery Pathways to the Lysosome01:36

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Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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mTOR Signaling and Cancer Progression03:03

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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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Updated: Jan 3, 2026

siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells
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Non-coding RNAs and Autophagy.

Honghong Yao1, Bing Han2, Yuan Zhang2

  • 1Department of Pharmacology, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China. yaohh@seu.edu.cn.

Advances in Experimental Medicine and Biology
|November 29, 2019
PubMed
Summary
This summary is machine-generated.

Non-coding RNAs (ncRNAs) are key regulators of cellular autophagy, a vital metabolic process. This review details ncRNA mechanisms in autophagy and their potential as disease biomarkers and therapeutic targets.

Keywords:
AutophagycircRNAslncRNAsmiRNAsncRNAs

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Area of Science:

  • Molecular Biology
  • Cellular Metabolism
  • Genetics

Background:

  • Autophagy is a fundamental cellular process for degrading damaged components and maintaining homeostasis.
  • Non-coding RNAs (ncRNAs) have emerged as critical regulators of various biological pathways, including autophagy.
  • Dysregulation of autophagy is implicated in numerous diseases.

Purpose of the Study:

  • To summarize the regulatory roles of diverse ncRNAs in autophagy.
  • To elucidate the detailed molecular mechanisms by which ncRNAs control autophagy.
  • To discuss the potential of ncRNAs as diagnostic, therapeutic, and prognostic tools in disease.

Main Methods:

  • Literature review and synthesis of existing research on ncRNA-mediated autophagy.
  • Analysis of molecular mechanisms underlying ncRNA-autophagy interactions.
  • Exploration of ncRNA functions in disease contexts related to autophagy.

Main Results:

  • Numerous ncRNAs (e.g., microRNAs, long non-coding RNAs) actively participate in modulating autophagy.
  • Specific ncRNAs influence different stages of the autophagy pathway through various molecular interactions.
  • ncRNAs demonstrate significant potential as biomarkers for disease diagnosis and prognosis.

Conclusions:

  • ncRNAs are integral to the intricate regulation of cellular autophagy.
  • Understanding ncRNA-autophagy crosstalk offers novel therapeutic strategies for diseases.
  • ncRNAs represent promising targets for developing advanced diagnostics and treatments.