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Trillions and Trillions: Herpes Simplex Virus-1 Hepatitis in an Immunocompetent Adult
Kevin Ikuta1, Pavitra Roychoudhury2, Hong Xie2
1Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.
Abstract:
We describe a case of acute liver failure and myopericarditis due to herpes simplex virus-1 (HSV-1) in an immunocompetent adult. We estimate that, at the height of viremia, the patient contained a quantity of HSV-1 virions approaching that of human cells. The patient recovered with acyclovir that was dose-adjusted for neurotoxicity and developed a vigorous anti-HSV-1 T-cell response.
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