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Role of Fibronectin in Primary Open Angle Glaucoma
Jennifer A Faralli1, Mark S Filla1, Donna M Peters1,2
1Departments of Pathology & Laboratory Medicine, University of Wisconsin, Madison, WI 53706, USA.
Cells
|November 30, 2019
Summary
Primary open angle glaucoma (POAG) increases intraocular pressure (IOP) due to fibronectin buildup in the trabecular meshwork. Changes in fibronectin fibrils may alter cell signaling, impacting IOP regulation.
Area of Science:
- Ophthalmology
- Cell Biology
- Biochemistry
Background:
- Primary open angle glaucoma (POAG) is a leading cause of irreversible vision loss.
- Elevated intraocular pressure (IOP) is a major risk factor for POAG.
- Fibronectin deposition in the trabecular meshwork (TM) is implicated in increased IOP.
Purpose of the Study:
- To explore the role of fibronectin and its fibrils in regulating intraocular pressure (IOP).
- To understand how fibronectin changes contribute to POAG pathogenesis.
Main Methods:
- Review of current literature on fibronectin, trabecular meshwork, and IOP.
- Analysis of proposed mechanisms linking fibronectin properties to IOP regulation.
Main Results:
- Increased fibronectin deposition in the TM is associated with elevated IOP.
- Altered fibronectin fibril density may affect TM compliance.
- Fibronectin fibril composition and organization can influence cell-matrix signaling in the TM.
Conclusions:
- Changes in fibronectin properties and fibril organization are potential contributors to IOP regulation in POAG.
- Further research is needed to elucidate the precise mechanisms by which fibronectin impacts IOP.
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