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Opening of coronary collaterals by repeated brief coronary occlusions in conscious dogs
M Fujita1, D P McKown, M D McKown
1Dalton Research Center, University of Missouri-Columbia.
Angiology
|November 1, 1988
Abstract:
The collateral blood flow and regional myocardial function during a one-minute coronary occlusion were compared before and after multiple one-minute coronary occlusions. After repeated coronary occlusions, the collateral blood flow velocity increased significantly from 0.7 +/- 0.1 (SE) to 2.0 +/- 0.2 cm/sec (p less than 0.05), and the blood flow debt repayment decreased from 326 +/- 26% to 189 +/- 12% (p less than 0.05). The systolic segment shortening in the collateral dependent zone improved slightly. Thus, the native coronary collateral vessels open in response to a repeated ischemic stimulus.