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Related Experiment Video

Updated: Jan 3, 2026

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Corticobasal degeneration.

Gerard M Saranza1, Jennifer L Whitwell2, Gabor G Kovacs3

  • 1Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, Ontario, Canada.

International Review of Neurobiology
|November 30, 2019
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Summary
This summary is machine-generated.

Corticobasal degeneration (CBD) is a rare tauopathy. Corticobasal syndrome (CBS) presents as parkinsonism with cortical dysfunction, but can have varied causes. Current treatments are symptomatic.

Keywords:
4R-tauopathyAtypical parkinsonismCorticobasal degenerationCorticobasal syndromeTauopathy

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Area of Science:

  • Neurology
  • Neuroscience
  • Pathology

Background:

  • Corticobasal degeneration (CBD) is a rare neurodegenerative disorder.
  • It is characterized by 4-repeat tau pathology in brain cells.
  • Corticobasal syndrome (CBS) is a clinical presentation of CBD, featuring asymmetric parkinsonism and cortical dysfunction.

Purpose of the Study:

  • To discuss clinical manifestations of pathologically confirmed CBD.
  • To review current diagnostic criteria for CBD and CBS.
  • To outline pathologic and neuroimaging findings in CBD/CBS.

Main Methods:

  • Review of clinical data from pathologically confirmed CBD cases.
  • Analysis of diagnostic criteria for CBD and CBS.
  • Examination of pathologic and neuroimaging findings.

Main Results:

  • CBD exhibits diverse clinical phenotypes.
  • CBS can be associated with pathologies other than CBD.
  • Current therapeutic options for CBD are symptomatic.

Conclusions:

  • Improved clinical diagnosis of CBD is crucial.
  • Further research into disease-modifying therapies for CBD is needed.
  • CBD/CBS requires enhanced diagnostic and therapeutic strategies.