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Updated: Jan 3, 2026

Evaluation of the Efficacy And Toxicity of RNAs Targeting HIV-1 Production for Use in Gene or Drug Therapy
Published on: September 5, 2016
Structure activity relationship, 6-modified purine riboside analogues to activate hSTING, stimulator of interferon
Laurent F Bonnac1, Christine D Dreis1, Robert J Geraghty1
1Center for Drug Design, College of Pharmacy, University of Minnesota, NHH, 312 Church St SE, Minneapolis, MN 55455, USA.
Abstract:
Twenty-nine nucleoside analogues have been synthesized and evaluated in a cell based assay for their ability to activate the human Stimulator of Interferon Genes (hSTING), a key protein of the innate immune defense. Some 6-O-alkyl nucleoside analogues activate hSTING without associated cytotoxicity. SAR and combination studies were performed to decipher possible activation mechanism. The described nucleoside hSTING activators represent first-in-class modulators of the innate immune defense; a highly relevant target for antiviral, antibacterial, anticancer or Alzheimer's disease treatments and may present advantages over other types of hSTING activators.
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