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Updated: Jan 2, 2026

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
Published on: November 21, 2013
Interaction of monomeric and self-assembled aromatic amino acids with model membranes: self-reproduction phenomena
Soumya Kanti De1, Anjan Chakraborty1
1Discipline of Chemistry, Indian Institute of Technology, Indore 453552, India. anjanc@iiti.ac.in.
Abstract:
The spontaneous formation of amyloid structures of proteins is responsible for several major human neurodegenerative diseases. Here, we demonstrate that the formation of amyloid aggregates of the amino acids results in the formation of supported phospholipid membrane and aggregated vesicles via fusion and self-reproduction of the lipid vesicles. Importantly, during the vesicle growth, we found the formation of large "mother vesicles" containing small "daughter vesicles". This observation is significant for interpreting the protein-membrane interaction and mimicking the origin of cellular life.
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