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Updated: Jan 2, 2026

Preparation and Use of Carbonyl-decorated Carbenes in the Activation of White Phosphorus
Published on: October 3, 2014
Triphenylphosphine-assisted dehydroxylative Csp3-N bond formation via electrochemical oxidation
Zhimin Xu1, Yue Zheng1, Zhihui Wang1
1Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China. tianlifang@njtech.edu.cn ias_yhwang@njtech.edu.cn.
Abstract:
A dehydroxylative Csp3-N coupling reaction assisted by triphenylphosphine has been developed through electrochemical oxidation. The reaction proceeds via anodic oxidation of triphenylphosphine to generate its corresponding radical cation, followed by reacting with hydroxyl groups to form alkoxy triphenylphosphonium ions, which are trapped by azoles or amides to construct C-N bonds. This method provides an efficient electrochemical strategy of activating hydroxyl groups to form C-N bonds under mild conditions.
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