Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

7.5K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
7.5K
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

3.9K
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
3.9K
The Ras Gene02:38

The Ras Gene

7.0K
The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...
7.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Perioperative Apalutamide in High-Risk Localized Prostate Cancer.

The New England journal of medicine·2026
Same author

Gender Disparities in Health-related Quality of Life Outcomes Following Radical Cystectomy for Bladder Cancer.

European urology focus·2025
Same author

Oncologic Outcomes of Template Versus Radioguided Salvage Lymph Node Dissection for Node-only Recurrent Prostate Cancer on Prostate-specific Membrane Antigen Positron Emission Tomography Scan: Results from a Multi-institutional Collaboration.

European urology focus·2025
Same author

Targeting All Multiple Magnetic Resonance Imaging Prostate Lesions Does Not Enhance Cancer Detection: Insights from the YAU Prostate Cancer Group.

European urology open science·2025
Same author

The Impact of Ureteral Access Sheaths on Radiation Exposure in the Ureterorenoscopic Treatment of Urolithiasis.

Urologia internationalis·2024
Same author

Optimizing risk stratification for intermediate-risk prostate cancer - the prognostic value of baseline health-related quality of life.

World journal of urology·2024

Related Experiment Video

Updated: Jan 2, 2026

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

17.0K

Hereditary prostate cancer - Primetime for genetic testing?

Isabel Heidegger1, Igor Tsaur2, Hendrik Borgmann2

  • 1Department of Urology, Medical University Innsbruck, Innsbruck, Austria.

Cancer Treatment Reviews
|November 30, 2019
PubMed
Summary

Hereditary prostate cancer (PCa) is linked to specific gene mutations. Genetic testing offers insights into PCa risk and personalized treatment, though its clinical use remains debated.

Keywords:
Genetic testingHereditaryPrecision oncologyProstate cancer

More Related Videos

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
10:40

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

2.7K
Cell-Free DNA Integrity Analysis in Urine Samples
07:58

Cell-Free DNA Integrity Analysis in Urine Samples

Published on: January 5, 2017

14.2K

Related Experiment Videos

Last Updated: Jan 2, 2026

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

17.0K
CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
10:40

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

2.7K
Cell-Free DNA Integrity Analysis in Urine Samples
07:58

Cell-Free DNA Integrity Analysis in Urine Samples

Published on: January 5, 2017

14.2K

Area of Science:

  • Oncology
  • Genetics
  • Epidemiology

Background:

  • Prostate cancer (PCa) is the most common cancer in men.
  • 5-15% of PCa cases are linked to high-risk hereditary factors.
  • Germline mutations (e.g., BRCA1, BRCA2, ATM, HOXB13) are associated with PCa incidence and progression.

Purpose of the Study:

  • To review the epidemiology and genetic basis of prostate cancer predisposition.
  • To critically discuss the clinical significance and consequences of germline testing.
  • To explore the impact of genetic testing on personalized therapy for advanced PCa.

Main Methods:

  • Literature review of epidemiological and genetic studies on prostate cancer.
  • Analysis of current genetic testing methodologies and clinical trial findings.
  • Discussion of clinical implications and controversies surrounding germline testing.

Main Results:

  • Identification of key genes (BRCA1, BRCA2, ATM, HOXB13) associated with hereditary PCa.
  • Germline mutations, SNPs, and copy number variations influence PCa risk and progression.
  • Ongoing clinical studies are evaluating the utility of genetic testing.

Conclusions:

  • Germline testing for hereditary prostate cancer is complex and debated.
  • Genetic insights are crucial for understanding PCa predisposition.
  • Genetic testing holds potential for personalized treatment strategies in advanced prostate cancer.