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Protocol to Create Chronic Wounds in Diabetic Mice
Published on: September 25, 2019
Complex Wound Management
Tom Shokri1, Sameep Kadakia2, Yadranko Ducic3
1Department of Otolaryngology, Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania.
Abstract:
Despite the generous blood supply, and resultant healing capacity within the head and neck, complex wounds in this area may be extremely debilitating and present an obstacle to treatment for the reconstructive surgeon. Delayed, incomplete, or otherwise suboptimal wound healing within this anatomical region may lead to both functional and aesthetically displeasing outcomes, resulting in impaired speech or swallowing, social stigma, and, in severe cases, exposure of critical underlying structures. Due to implications, with regard to wound formation following surgical intervention, the facial reconstructive surgeon, in particular, must be familiar with the multitude of treatment modalities available. This article serves as a review of the underlying pathophysiology of wound healing, local and systemic processes that may influence the healing process, and treatments that facilitate tissue restoration while mitigating future complications.
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