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Updated: Jan 2, 2026

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies
Published on: August 25, 2018
Impact of Vaping Regimens on Electronic Cigarette Efficiency
Sébastien Soulet1,2, Marie Duquesne3, Jean Toutain3
1Ingesciences, 2 Chemin des Arestrieux, 33610 Cestas, France.
Direct-to-lung (DTL) inhalation studies for electronic cigarettes (e-cigs) are lacking. This research defines an intense vaping regimen for DTL, finding it optimizes e-liquid vaporization and device efficiency.
Area of Science:
- Chemical Engineering
- Toxicology
- Material Science
Background:
- Most electronic cigarette (e-cig) research uses mouth-to-lung (MTL) inhalation, not direct-to-lung (DTL) inhalation.
- Limited data exists on DTL inhalation parameters and their impact on e-liquid vaporization.
- Standardized vaping protocols are crucial for reproducible e-cig research.
Purpose of the Study:
- To characterize the influence of inhalation properties on mass of vaporized e-liquid (MVE).
- To define and evaluate an intense vaping regimen suitable for DTL inhalation.
- To analyze e-cig efficiency under various vaping conditions and atomizer resistances.
Main Methods:
- Defined an intense vaping regimen (500 mL puff volume) simulating DTL inhalation.
- Compared standard (ISO/DIS 20768) and intense regimens using a Cubis 1 Ω atomizer across a power range.
- Tested two sub-ohm and two above-ohm atomizers under their respective power ranges.
- Calculated e-cig efficiency for MVE under different conditions.
Main Results:
- The intense vaping regimen enabled a wider power range under optimal heating.
- Mass of vaporized e-liquid (MVE) increased linearly with power until overheating.
- E-cig efficiencies were higher with low-resistance atomizers at high powers.
- Vapor evacuation improved with the intense vaping regimen.
Conclusions:
- An intense vaping regimen is necessary for DTL inhalation studies.
- Standardized DTL vaping protocols are needed for accurate e-cig research.
- Inhalation patterns significantly affect e-liquid vaporization and device performance.
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10:44Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System
Published on: May 24, 2017
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