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Related Experiment Video

Updated: Jan 2, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Cognitive processing speed deficits in multiple sclerosis: Dissociating sensorial and motor processing changes from

M Clough¹, J Dobbing², J Stankovich¹

¹Department of Neurosciences, Central Clinical School, Monash University, Alfred Centre, Commercial Rd, Melbourne, VIC, 3004, Australia.

Multiple Sclerosis and Related Disorders

|December 1, 2019

Summary

This summary is machine-generated.

Multiple sclerosis (MS) patients show impaired cognitive information processing speed (IPS) and conflict resolution, distinct from sensory or motor deficits. The Symbol Digit Modalities Test (SDMT) may inaccurately measure cognitive IPS in MS.

Keywords:

Cognition Information processing speed Multiple sclerosis Ocular motor

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Area of Science:

Neuroscience
Cognitive Science
Neurology

Background:

Assessing cognitive information processing speed (IPS) in multiple sclerosis (MS) is challenging.
Performance on tests like the Symbol Digit Modalities Test (SDMT) may reflect sensory/motor changes, not solely cognitive deficits.
Distinguishing cognitive IPS from sensory and motor processing is crucial for accurate MS assessment.

Purpose of the Study:

To isolate and characterize cognitive IPS deficits in MS using ocular motor tasks.
To differentiate cognitive IPS from sensorial and motor information processing speed.
To evaluate the validity of the SDMT in measuring cognitive IPS in MS.

Main Methods:

Utilized ocular motor tasks, including a prosaccade task to control for sensorial/motor IPS.
Employed a Simon task with congruent and incongruent trials to assess cognitive IPS.
Compared performance between 22 early MS patients and 22 healthy controls, alongside the SDMT.

Main Results:

MS patients showed no difference from controls on the SDMT.
When sensorial and motor IPS were controlled, MS patients exhibited slower cognitive IPS (incongruent trials) and poorer conflict resolution.
SDMT performance did not correlate with cognitive IPS deficits in MS patients.

Conclusions:

Cognitive IPS deficits in MS are distinct from other processing stages, characterized by impaired conflict resolution.
The findings question the accuracy of the SDMT for measuring cognitive IPS in MS.
Ocular motor tasks offer a more precise method for assessing cognitive IPS in MS.