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Developmental Differences in Platelet Inhibition Response to Prostaglandin E1

Verónica Palma-Barqueros1, José Miguel Torregrosa1,2, Eva Caparrós-Pérez1

  • 1Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, IMIB-Arrixaca, CB15/00055-CIBERER, Murcia, Spain.

Neonatology
|December 2, 2019
PubMed
Summary

Neonatal platelets are more sensitive to prostaglandin E1 (PGE1) inhibition due to a more active PGE1-cAMP-PKA signaling pathway. This explains why neonatal platelets are hyporesponsive compared to adult platelets.

Keywords:
Cyclic adenosine 3′5′-monophosphateInhibitory signaling pathwaysNeonatal plateletsProstaglandin E1

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