[Microphysiological system as a promising technology for drug assay].

Area of Science:

• Biotechnology
• Pharmacokinetics
• In-vitro modeling

Background:

• Microphysiological systems (MPS) are advanced in-vitro cell-culture environments.
• Utilizing micro electro mechanical systems (MEMS) technology, MPS create microspaces for human cells to exhibit in-vivo-like functions.
• From a pharmacokinetic perspective, MPS function as wet PBPK/PD simulators.

Purpose of the Study:

• To review microphysiological systems (MPS) for pharmacokinetic applications.
• To identify and characterize different types of cell culture units within MPS.
• To discuss technical requirements for MPS cell culture units and their commercialization.

Main Methods:

• Identification and classification of cell culture unit types in MPS for pharmacokinetics.
• Overview of the characteristics of each identified cell culture unit type.
• Discussion of technical requirements for cell-culture environmental design and cell function within MPS.

Main Results:

• Two primary types of cell culture units for pharmacokinetic MPS were identified.
• Characteristics of each cell culture unit type were detailed.
• Technical requirements for cell culture environment and function were discussed.

Conclusions:

• MPS represent a significant advancement in in-vitro pharmacokinetic modeling.
• Understanding cell culture unit design and function is crucial for effective MPS development.
• The global commercialization landscape of MPS is evolving.