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Updated: Jan 2, 2026
An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
Published on: December 3, 2020
[Microphysiological system as a promising technology for drug assay]
Seiichi Ishida1, Toshiyuki Kanamori2
1National Institute of Health Sciences.
Abstract:
MPS (microphysiological system) is in-vitro cell-culture environment, which is precisely maintained in a micro space manufactured using MEMS (micro electro mechanical systems) technology, to derive in-vivo like functions from human cells. From the viewpoint of pharmacokinetics, it can be considered as a wet PBPK/PD simulator consisting of the micro organs (cell culture units) connected each other with a circulating medium, which mimic the organs responsible for the drug's ADME (absorption-distribution-metabolism-elimination). In this review, we identify two types of the cell culture units consisting of the MPS for pharmacokinetics, and overview the characteristics of each type. Then, we discuss about the technical requirements needed for the cell culture unit from the point of view of both cell-culture environmental design and cell function, and introduce the world-wide current situation of the commercialization of the MPS.
Insights
Microphysiological systems (MPS) offer in-vivo-like cell functions for pharmacokinetic simulations. This review details MPS cell culture unit types, technical needs, and global commercialization status.
Area of Science:
- Biotechnology
- Pharmacokinetics
- In-vitro modeling
Background:
- Microphysiological systems (MPS) are advanced in-vitro cell-culture environments.
- Utilizing micro electro mechanical systems (MEMS) technology, MPS create microspaces for human cells to exhibit in-vivo-like functions.
- From a pharmacokinetic perspective, MPS function as wet PBPK/PD simulators.
Purpose of the Study:
- To review microphysiological systems (MPS) for pharmacokinetic applications.
- To identify and characterize different types of cell culture units within MPS.
- To discuss technical requirements for MPS cell culture units and their commercialization.
Main Methods:
- Identification and classification of cell culture unit types in MPS for pharmacokinetics.
- Overview of the characteristics of each identified cell culture unit type.
- Discussion of technical requirements for cell-culture environmental design and cell function within MPS.
Main Results:
- Two primary types of cell culture units for pharmacokinetic MPS were identified.
- Characteristics of each cell culture unit type were detailed.
- Technical requirements for cell culture environment and function were discussed.
Conclusions:
- MPS represent a significant advancement in in-vitro pharmacokinetic modeling.
- Understanding cell culture unit design and function is crucial for effective MPS development.
- The global commercialization landscape of MPS is evolving.
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