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Published on: June 6, 2025
The AP-1 pathway; A key regulator of cellular transformation modulated by oncogenic viruses
Habibollah Mirzaei1,2, Nastaran Khodadad2,3, Chiman Karami2,3
1Hepatitis Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
Abstract:
Cancer progression is critically associated with modulation of host cell signaling pathways. Activator protein-1 (AP-1) signaling is one such pathway whose deregulation renders the host more susceptible to cancer development. Oncogenic viruses, including hepatitis B virus, hepatitis C virus, human papilloma virus, Epstein-Barr virus, human T-cell lymphotropic virus type 1, and Kaposi's sarcoma-associated herpes virus, are common causes of cancer. This review discusses how these oncoviruses by acting through various aspects of the host cell signaling machinery such as the AP-1 pathway might affect oncoviral tumorigenesis, replication, and pathogenesis. The review also briefly considers how the pathway might be targeted during infections with these oncogenic viruses.
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