Related Experiment Video
Updated: Jan 13, 2026

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
Human papillomavirus infection and its association with lung cancer: a case-control study (2011-2019)
Zanyar Shakeri1, Manoochehr Makvandi1, Habibollah Mirzaei1
1Cancer Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Background And Objectives:
Human papillomavirus (HPV) causes about 4.5% of all new human cancers. The purpose of this study was to look into the prevalence of various HPV types in patients with lung cancer.
Materials And Methods:
The study included a cohort of 61 individuals who had received treatment at Imam Khomeini Hospital in Ahvaz between 2011 and 2019. Paraffin-embedded tissues were used for molecular analysis. The primary goal was to assess the differences in HPV prevalence between lung cancer patients and a control group, using a Nested PCR assay followed by sequencing.
Results:
Among the lung cancer patients, HPV DNA was detected in 10 individuals, while three individuals in the control group were also positive (16.3% versus 12.0%, P=0.65). Notably, every detected HPV variant was classified as the high-risk type 16. Additionally, the researchers investigated potential associations between age, sex, smoking habits, and lung cancer in both HPV-positive and negative patients. The study findings revealed that age, sex, and smoking habits did not show statistically significant associations with the presence of HPV (P>0.05). Moreover, Lung cancer incidence was not significantly correlated with HPV infection (P>0.05).
Conclusion:
Therefore, according to the study's findings, smoking, HPV infection, and lung cancer prevalence were not significantly correlated in the population under investigation.
More Related Videos
06:57Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
Published on: June 14, 2019
07:43Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples
Published on: July 29, 2017
Related Concept Videos
Cancer Prevention
Some...
Statistical Methods for Analyzing Epidemiological Data
Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Single Nucleotide Polymorphisms-SNPs