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Isolated tumour microparticles induce endothelial microparticle release in vitro
Lucy G Faulkner1, Saeed Alqarni2, Anthony Maraveyas1
1Queens Centre for Oncology and Haematology, Castle Hill Hospital, Cottingham.
Summary
Cancer-associated microparticles, not soluble tissue factor (TF), drive blood clot risk by activating endothelial cells. Tumor microparticles increase endothelial cell microparticle release, suggesting a mechanism for cancer-induced hypercoagulability.
Area of Science:
- Oncology
- Hematology
- Cell Biology
Background:
- Cancer patients have an elevated risk of venous thromboembolism due to a hypercoagulable state.
- Tumor-derived tissue factor (TF) released in microparticles is a key factor contributing to this prothrombotic state.
- Previous studies showed tumor media induces procoagulant changes in human umbilical vein endothelial cells (HUVEC).
