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Related Experiment Video

Updated: Jan 2, 2026

Simultaneous Recording of Electroretinography and Visual Evoked Potentials in Anesthetized Rats
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Spatial-sweep steady-state pattern electroretinography can detect subtle differences in visual function among healthy

Sakiko Minami1,2,3, Norihiro Nagai1,4, Misa Suzuki1,5

  • 1Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.

Scientific Reports
|December 4, 2019
PubMed
Summary

Spatial-sweep steady-state pattern electroretinography (swpPERG) offers a sensitive method for visual function measurement. This technique correlates with age and macular structure, aiding future early disease detection.

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Biomedical Engineering

Background:

  • Accurate measurement of visual function is crucial for diagnosing eye diseases and monitoring treatment efficacy.
  • Current methods may lack the sensitivity to detect subtle changes in retinal function.
  • Spatial-sweep steady-state pattern electroretinography (swpPERG) is a developing technique for assessing visual pathways.

Purpose of the Study:

  • To establish a highly sensitive method for measuring visual function using spatial-sweep steady-state pattern electroretinography (swpPERG).
  • To investigate the correlation between swpPERG signal-to-noise ratios (SNR) and participant age and macular morphology in healthy adults.

Main Methods:

  • 35 healthy adults underwent swpPERG using the EvokeDx system with varying stimulus sizes (1-6).
  • Data were analyzed in the frequency domain using Fourier transform to calculate SNR.
  • Macular volume was assessed using optical coherence tomography (OCT).

Main Results:

  • SNR values were significantly lower at larger stimulus sizes (5 and 6).
  • Higher SNRs correlated with younger age at stimulus size 5.
  • SNR positively correlated with retinal nerve fibre layer volume (size 4) and ganglion cell layer volume (size 5).

Conclusions:

  • swpPERG, recorded with the EvokeDx system, provides sensitive measurements of visual function.
  • The technique's findings correlate with age and macular morphology in healthy individuals.
  • swpPERG shows potential for early disease diagnosis and evaluating neuroprotective interventions.