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Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
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A signaling cascade is a series of events that facilitates the transmission of information within or between cells, culminating in a targeted response in the recipient cell. As chemical messengers, hormones are pivotal in initiating and modulating these intricate signaling cascades based on their solubility.
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Interplay between morphogen-directed positional information systems and physiological signaling.

Francisco Huizar1,2, Dharsan Soundarrajan1, Ramezan Paravitorghabeh1

  • 1Department of Chemical and Biomolecular Engineering, University of Notre Dame, South Bend, Indiana.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|December 4, 2019
PubMed
Summary
This summary is machine-generated.

Physiological signaling complements morphogen gradients for robust spatial patterning during development. Understanding this interplay is key for development, disease, and regeneration research.

Keywords:
bioelectricitycalcium signalingmorphogenmorphogenesisneurotransmission

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Area of Science:

  • Developmental Biology
  • Systems Biology
  • Cellular Signaling

Background:

  • Organismal development requires spatial patterning of cell fates, guided by positional information and morphogen gradients.
  • Mechanisms of morphogen gradient establishment, maintenance, and interpretation remain incompletely understood.
  • Quantitative and systems-based approaches are crucial for defining biological design rules in positional information systems.

Purpose of the Study:

  • To review studies on physiological signaling's role in morphogen-based pattern formation.
  • To explore shared principles between neural transmission and morphogen signaling.
  • To highlight the impact of physiological signaling on developmental robustness and interpretation.

Main Methods:

  • Selective literature review focusing on physiological signaling in pattern formation.
  • Comparative analysis of neural transmission and morphogen signaling mechanisms.
  • Synthesis of evidence on the role of physiological signaling in developmental robustness.

Main Results:

  • Physiological signaling actively modulates and mediates morphogen-based pattern formation.
  • Neural networks utilize physiological signaling for directed information, supplementing diffusion-based positional cues.
  • Evidence indicates physiological signaling enhances the robustness of morphogen-based signaling pathways.

Conclusions:

  • Physiological signaling plays a critical role in ensuring the robustness of morphogen-based pattern formation.
  • Shared principles exist between active cell-based communication in neural transmission and development.
  • Further research is needed to fully elucidate the impact of physiological signaling on positional information and its implications for development, disease, and regeneration.