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lncRNA - Long Non-coding RNAs02:39

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Long non-coding RNAs and pyroptosis.

Dong He1, Jun Zheng2, Jia Hu3

  • 1Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, China; School of Nursing, Xiangnan University, Chenzhou, Hunan 423000, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|December 4, 2019
PubMed
Summary
This summary is machine-generated.

Long noncoding RNAs (lncRNAs) regulate pyroptosis, a programmed cell death linked to inflammation and disease. This review explores lncRNA roles in pyroptosis for new therapeutic strategies.

Keywords:
Long non-coding RNAsPyroptosisRelationship

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Area of Science:

  • Molecular Biology
  • Genetics
  • Cellular Biology

Background:

  • Long noncoding RNAs (lncRNAs) are RNA transcripts over 200 nucleotides with limited protein-coding potential.
  • lncRNAs influence disease progression via epigenetic, transcriptional, and post-transcriptional regulation.
  • Emerging evidence highlights lncRNAs' critical role in regulating pyroptosis, a key inflammatory cell death pathway.

Purpose of the Study:

  • To review the regulatory functions of lncRNAs in pyroptosis.
  • To explore the involvement of lncRNAs in pyroptosis-related diseases.
  • To provide insights for lncRNA-based therapeutic strategies targeting pyroptosis.

Main Methods:

  • Literature review of recent studies on lncRNAs and pyroptosis.
  • Analysis of lncRNA expression characteristics.
  • Examination of lncRNA interactions within the pyroptosis signaling pathway.

Main Results:

  • lncRNAs directly or indirectly modulate proteins within the pyroptosis pathway.
  • Dysregulated lncRNA expression is implicated in cardiovascular, kidney, and immune diseases via pyroptosis.
  • lncRNAs serve as crucial regulators in the pathological processes of pyroptosis-related conditions.

Conclusions:

  • lncRNAs play a significant role in controlling pyroptosis.
  • Understanding lncRNA-mediated pyroptosis offers novel avenues for disease treatment.
  • Further research into lncRNAs can lead to innovative therapies for pyroptosis-associated pathologies.