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Experimental studies on fluosol DA administration in acute pancreatitis
H Ohyanagi1, O Ohashi, S Nakayama
1First Department of Surgery, School of Medicine, Kobe University, Japan.
Biomaterials, Artificial Cells, and Artificial Organs
|January 1, 1988
Summary
Fluosol DA, a perfluorochemical emulsion, improved pancreatic blood flow and oxygen supply in dogs with acute pancreatitis. While not fully improving survival, it showed promise in preserving pancreatic function and protecting organs.
Area of Science:
- Biomedical Engineering
- Surgical Research
- Emergency Medicine
Background:
- Acute pancreatitis is a severe condition often exacerbated by compromised pancreatic blood flow and oxygenation.
- Maintaining local tissue perfusion and oxygen supply is crucial for managing acute pancreatitis.
- Perfluorochemical emulsions have been explored for their oxygen-carrying capacity.
Purpose of the Study:
- To evaluate the therapeutic potential of Fluosol DA in mitigating acute pancreatitis.
- To investigate the effects of Fluosol DA on pancreatic blood flow, oxygen tension, and mitochondrial function.
- To assess the impact of Fluosol DA on systemic organ protection in a canine model of acute pancreatitis.
Main Methods:
- Acute pancreatitis was induced in dogs using deoxycholate injection into the pancreatic duct.
- Animals received either Fluosol DA or hydroxyethylstarch (HES) solution intravenously.
- Cardiac output, pancreatic blood flow, pancreatic tissue oxygen tension, mitochondrial function, and plasma enzyme levels were monitored.
Main Results:
- Both Fluosol DA and HES improved cardiac output and pancreatic blood flow.
- Fluosol DA significantly increased pancreatic tissue oxygen tension compared to HES.
- Fluosol DA demonstrated better preservation of pancreatic mitochondrial function and suggested protection of systemic organs.
Conclusions:
- Fluosol DA effectively maintains pancreatic blood flow and enhances oxygen transport in acute pancreatitis.
- The improved oxygenation and organ preservation suggest a positive role for Fluosol DA in inhibiting pancreatitis progression.
- Fluosol DA alone provided incomplete improvement in survival rates for acute pancreatitis.