Meningioma with rosettes: A rare morphologic pattern.

Area of Science:

• Neuropathology
• Oncology
• Histopathology

Background:

• Meningiomas are tumors arising from the meninges, with WHO grade I representing benign tumors.
• Rosettes are a histological feature characterized by cells arranged around a central lumen or core, often indicative of neuronal or ependymal differentiation.
• While rosettes are common in certain central nervous system (CNS) tumors, their occurrence in meningiomas is infrequent.

Observation:

• A case of a 68-year-old female patient with a WHO grade I transitional meningioma was analyzed.
• The meningioma exhibited a distinct rosette formation.
• These rosettes were histologically characterized by meningothelial cells surrounding dense collagenous cores.

Findings:

• The study identified a rare morphological variant of meningioma, specifically a transitional meningioma with a rosette pattern.
• The presence of rosettes, typically associated with neuronal or ependymal differentiation, was observed in a meningioma, a tumor of non-neuronal origin.
• This finding underscores that rosette formation is not exclusive to neuroectodermal tumors and can appear in other neoplastic lineages.

Implications:

• The recognition of rosette formation in meningiomas is crucial for accurate histopathological diagnosis and classification.
• This case expands the understanding of meningioma morphology, highlighting the importance of considering differential diagnoses when encountering rosette-like structures.
• Further research into the pathogenesis and clinical significance of rosettes in meningiomas may be warranted.