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Age-related changes of muscimol binding in the substantia nigra
J N Wurpel1, A Tempel, E F Sperber
1Department of Neurology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY 10461.
Brain Research
|October 1, 1988
Abstract:
Receptor binding studies of the substantia nigra (SN) and cerebellum revealed two affinity sites for muscimol binding in the SN and cerebellum of adult and 16-day-old rats. Scatchard analysis revealed a paucity of high-affinity muscimol receptors in the SN of 16-day-old rat pups. These results suggest that the lack of anticonvulsant action of muscimol in the SN of 16-day-old rat pups may be due to the paucity of high-affinity muscimol receptors as compared to adult rats.