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Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

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Published on: February 6, 2019

Event-Related Potentials and Cognitive Function in Alcoholism.

Bernice Porjesz¹, Henri Begleiter¹

¹Bernice Porjesz, Ph.D., is an assistant professor in the Department of Psychiatry, State University of New York Health Science Center, Brooklyn, New York. Henri Begleiter, M.D., Ph.D., is a professor of psychiatry and neuroscience in the Department of Psychiatry, State University of New York Health Science Center, Brooklyn, New York.

Alcohol Health and Research World

|December 5, 2019

Summary

Event-related potentials (ERPs) reveal cognitive deficits in alcoholics. Anomalies in nonalcoholic individuals with alcoholic family histories suggest these brain wave patterns may precede alcoholism.

Keywords:

AOD abstinence AOD dependence AOD impairment biological markers cognitive process evoked potential memory sensory stimuli

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Area of Science:

Neuroscience
Cognitive Psychology
Addiction Research

Background:

Subtle cognitive deficits are measurable using event-related potentials (ERPs).
Alcoholism is associated with impaired memory processes, requiring novel stimulus evaluation.
ERPs may serve as a biomarker for predisposition to alcoholism.

Purpose of the Study:

To investigate the utility of ERPs in studying cognitive deficits related to alcoholism.
To explore ERP anomalies in nonalcoholic individuals with familial alcohol exposure.
To determine if ERP anomalies can predict the development of alcoholism.

Main Methods:

Utilizing event-related potentials (ERPs) to measure brain responses to stimuli.
Analyzing ERP data to identify cognitive processing differences.
Comparing ERP patterns in alcoholics, nonalcoholics with alcoholic family history, and control groups.

Main Results:

ERP studies indicate impaired memory processes in alcoholics.
Nonalcoholic subjects from alcoholic families exhibit specific ERP anomalies.
These ERP anomalies may precede the clinical manifestation of alcoholism.

Conclusions:

ERPs are a valuable tool for detecting subtle cognitive deficits in alcoholism.
Familial risk for alcoholism is associated with distinct neurophysiological markers.
ERP anomalies could serve as early indicators of vulnerability to alcohol use disorder.