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Genetic Engineering in Animal Models.

Susanne Hiller-Sturmhöfel1, Barbara J Bowers1, Jeanne M Wehner1

  • 1Susanne Hiller-Sturmhöfel, Ph.D., is a science editor of Alcohol Health & Research World. Barbara J. Bowers, Ph.D., is a research associate in the Department of Psychiatry, Indiana University, Indianapolis, Indiana. Jeanne M. Wehner, Ph.D., is a professor at the Institute for Behavioral Genetics at the University of Colorado at Boulder, Boulder, Colorado.

Alcohol Health and Research World
|December 5, 2019
PubMed
Summary
This summary is machine-generated.

New genetic technologies in laboratory animals, like transgenic and knockout mice, help study alcoholism causes. These methods offer insights into genetic and environmental factors influencing alcohol use disorders.

Keywords:
AOD dependenceRNAanimal modelanimal strainsgenegenetics and heredityresearch

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Area of Science:

  • Genetics
  • Neuroscience
  • Pharmacology

Background:

  • Alcoholism is a complex disorder influenced by multiple genetic and environmental factors.
  • Understanding the specific genetic contributions to alcoholism is crucial for developing effective treatments.

Purpose of the Study:

  • To explore the application of novel genetic technologies in laboratory animals for studying the genetic basis of alcoholism.
  • To evaluate the potential of these techniques in providing new insights into the causes and consequences of alcohol use disorders.

Main Methods:

  • Utilizing transgenic mice to permanently insert foreign genes.
  • Employing knockout mice to permanently inactivate specific genes.
  • Applying antisense ribonucleic acid (RNA) treatment for temporary gene inactivation.

Main Results:

  • These genetic technologies enable in vivo studies of gene function related to alcoholism.
  • The methods allow for precise manipulation of the animal's genetic material to observe effects on alcohol-related behaviors.

Conclusions:

  • Advanced genetic technologies in animal models offer powerful tools for investigating the etiology of alcoholism.
  • These approaches promise to enhance our understanding of the complex interplay between genes and environment in alcohol dependence.