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Evaluation of oxaliplatin-induced pulmonary toxicity in rats
Serdar Kalemci1, Ozgür Tanrıverdi2, Abdullah Şimşek3
1Department of Chest Diseases, Faculty of Medicine, Sitki Kocman University, Mugla, Turkey.
Introduction:
The mechanism of oxaliplatin (OXA) induced pulmonary toxicity is not fully understood.
Aim Of The Study:
The present study was designed to investigate the pulmonary toxicity of OXA that has been reported in previous studies. Study design: animal experiments.
Material And Methods:
A total of 40 female Wistar rats were divided into 5 groups. In group 1, 5% glucose was injected intra-peritoneally; then the rats were sacrificed on day 14. OXA was administered in groups 2, 3, 4, and 5; then the animals were sacrificed on day 7 in group 2, day 14 in group 3, day 28 in group 4 and day 48 in group 5. The groups were further categorized as short-term administration and long-term administration groups. Furthermore, tissue glutathione peroxidase (GPX) activity was measured in all rats.
Results:
The mean GPX activities were 0.66 U/mg in the sham group, 0.74 U/mg in the short-term groups, and 0.74 U/mg in the long-term groups. We found that long-term OXA administration causes pulmonary toxicity resulting in increased intra-alveolar/interstitial macrophages and interstitial pneumonia. Similarly, we found reduced and permanent tissue GPX activity in rats that received OXA in higher doses and for a long term.
Conclusions:
Long-term OXA therapy causes toxic changes in the lung tissue.
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