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Non-coding RNA in drug resistance of gastric cancer
Ya-Jun Luo1, Qing-Mei Huang2, Yan Ren1
1Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chengdu Medical College, Chengdu 610500, Sichuan Province, China.
Abstract:
Gastric cancer (GC) is the third leading cause of cancer-related mortality worldwide. The poorly prognosis and survival of GC are due to diagnose in an advanced, non-curable stage and with a limited response to chemotherapy. The acquisition of drug resistance accounts for the majority of therapy failure of chemotherapy in GC patients. Although the mechanisms of anticancer drug resistance have been broadly studied, the regulation of these mechanisms has not been completely understood. Accumulating evidence has recently highlighted the role of non-coding RNAs (ncRNAs), including long non-coding RNAs and microRNAs, in the development and maintenance of drug resistance due to their regulatory features in specific genes involved in the chemoresistant phenotype of GC. We review the literature on ncRNAs in drug resistance of GC. This review summarizes the current knowledge about the ncRNAs' characteristics, their regulation of the genes involved in chemoresistance and their potential as targeted therapies for personalized treatment in resistant GC.
Insights
Non-coding RNAs (ncRNAs) are key regulators in gastric cancer (GC) drug resistance. Understanding these ncRNAs offers potential for targeted therapies to improve treatment outcomes for patients with resistant GC.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Gastric cancer (GC) is a leading cause of cancer mortality globally.
- Advanced stage diagnosis and chemotherapy resistance significantly limit treatment efficacy and patient survival.
- Mechanisms underlying drug resistance in GC are not fully understood, hindering effective therapeutic strategies.
Purpose of the Study:
- To review the current literature on the role of non-coding RNAs (ncRNAs) in gastric cancer drug resistance.
- To summarize the characteristics of ncRNAs and their regulatory functions in chemoresistance.
- To explore the potential of ncRNAs as therapeutic targets for personalized treatment in resistant GC.
Main Methods:
- Comprehensive literature review of studies investigating ncRNAs in GC drug resistance.
- Analysis of ncRNA characteristics and their involvement in chemoresistance pathways.
- Evaluation of ncRNAs as potential biomarkers and therapeutic targets.
Main Results:
- Non-coding RNAs, including long non-coding RNAs and microRNAs, play a crucial role in the development and maintenance of GC drug resistance.
- ncRNAs regulate specific genes associated with the chemoresistant phenotype in GC.
- ncRNAs demonstrate potential as targets for novel therapeutic strategies.
Conclusions:
- ncRNAs are significant regulators of chemotherapy resistance in gastric cancer.
- Targeting ncRNAs presents a promising avenue for developing personalized and effective treatments for resistant GC.
- Further research into ncRNA mechanisms can enhance therapeutic outcomes for GC patients.
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