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High factor VIII levels and arterial thrombosis: illustrative case and literature review

Farjah Hassan Algahtani1, Ruth Stuckey2

  • 1Hematology-Oncology Division, Department of Medicine, College of Medicine, King Saud University, Riyadh 11472, Saudi Arabia.

Therapeutic Advances in Hematology
|December 5, 2019
PubMed

Insights

High factor VIII levels increase the risk of both venous and arterial thrombosis. While a risk factor, routine testing for high factor VIII is not recommended due to inconsistent lab methods.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Genetics

Background:

  • Thrombotic disorders are a major cause of death globally.
  • Genetic factors contribute to venous thrombosis risk, with high factor VIII levels being a known risk factor for venous thrombosis and coronary artery disease.
  • The genetic basis for arterial thrombosis predisposition is less understood.

Observation:

  • Presents a case of a 32-year-old Saudi Arabian patient with peripheral arterial thrombosis.
  • The patient's sole identified risk factor was elevated factor VIII levels.
  • Reviews current knowledge on high factor VIII levels and arterial thrombosis/ischemic heart disease risk.

Findings:

  • High factor VIII levels are confirmed as a risk factor for thrombosis.
  • The impact of high factor VIII levels is greater on venous thrombosis than arterial thrombosis.
  • The study highlights a potential link between high factor VIII and arterial events.

Implications:

  • Suggests high factor VIII levels may play a role in arterial thrombosis, though less than in venous thrombosis.
  • Lack of standardized laboratory testing for factor VIII levels hinders clinical application.
  • Recommends against routine factor VIII level measurement in thrombophilia screening due to current limitations.

Keywords:
blood groupgenetic risk factorsischemic heart diseasemyocardial infarctionthrombophiliavon Willebrand factor

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