Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Selective and marked decrease of complement receptor C5aR2 in human thoracic aortic aneurysms: a dysregulation with

Margrethe Flesvig Holt1,2, Bjørn E Seim1,2,3, Jonas Øgaard2

  • 1Institute of Clinical Medicine, University of Oslo Faculty of Medicine, Oslo, Norway.

Open Heart
|December 5, 2019
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of tofacitinib on growth in patients with juvenile idiopathic arthritis.

Annals of the rheumatic diseases·2026
Same author

Mucosal-Associated Invariant T Cells Drive Bile Duct Inflammation.

Cellular and molecular gastroenterology and hepatology·2026
Same author

Intrahepatic T cell analysis reveals Th17 and MAIT17 enrichment in primary sclerosing cholangitis.

JHEP reports : innovation in hepatology·2026
Same author

Risk of serious infections, myocardial infarction or stroke, venous thromboembolic events, and malignancy in patients with psoriatic arthritis treated with tofacitinib compared with biologic treatments in the United States.

Arthritis research & therapy·2026
Same author

Patients' Perspectives Regarding Ankylosing Spondylitis Treatment Administration Features: Evidence from Qualitative Interviews and a Multinational Quantitative Preference Survey.

Rheumatology and therapy·2026
Same author

Natural Killer T cells promote cholestatic liver disease independent of antigen presentation by cholangiocytes.

Hepatology communications·2026
This summary is machine-generated.

Thoracic aortic aneurysm (TAA) is linked to reduced expression of the anti-inflammatory receptor C5aR2. This downregulation may promote inflammation, contributing to TAA development and progression.

Area of Science:

  • Immunology
  • Cardiovascular Biology
  • Molecular Medicine

Background:

  • Thoracic aortic aneurysm (TAA) pathogenesis is poorly understood, with inflammation suspected as a key factor.
  • Complement receptors are implicated in inflammatory processes, but their specific role in TAA remains unclear.

Purpose of the Study:

  • To investigate the expression and role of complement receptors, specifically C3aR1, C5aR1, and C5aR2, in patients with TAA.
  • To determine if complement receptor expression differs between TAA patients and controls with other cardiovascular conditions.

Main Methods:

  • Quantitative RT-PCR and immunohistochemistry were used to assess C5aR2 mRNA and protein expression in aortic tissue from TAA patients and controls.
  • Immunofluorescence was employed to localize C5aR2 within aortic tissue.
Keywords:
aorta, great vessels and traumaaortic diseaseaortic valve diseaseinflammation

Related Experiment Videos

  • Plasma levels of complement activation products were measured.

    • Main Results:

    • TAA patients exhibited significantly downregulated C5aR2 gene and protein expression compared to controls (p=0.005 and p=0.03, respectively).
    • No significant differences were observed in C3aR1 and C5aR1 expression between the groups.
    • C5aR2 was found to colocalize with macrophages and T cells in the aortic media of TAA patients.

    Conclusions:

    • Downregulation of the primarily anti-inflammatory C5aR2 in TAA may shift the balance towards pro-inflammatory responses mediated by C5aR1.
    • This altered receptor expression could contribute to the enhanced inflammatory processes observed in TAA pathogenesis.