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Glycemia and Lipidemia in Term Newborns Correlate With Maternal Metabolism

Hugo Razini Oliveira1, Beatriz Rosana Gonçalves de Oliveira Toso1, Ana Tereza Bittencourt Guimarães1

  • 1Western Paraná State University, Cascavel, Paraná, Brazil.

Global Pediatric Health
|December 5, 2019
PubMed

Insights

Maternal pregnancy conditions may influence newborn metabolic programming. While babies

Area of Science:

  • Endocrinology
  • Neonatology
  • Metabolic Programming

Background:

  • Maternal health during pregnancy significantly impacts newborn metabolic health.
  • Understanding the influence of maternal conditions on infant metabolic programming is crucial for long-term health outcomes.
  • Gestational weight gain and maternal metabolic status are key factors to consider.

Purpose of the Study:

  • To characterize plasma glycemic and lipid profiles in term newborns.
  • To correlate these profiles with growth markers and maternal clinical/metabolic conditions.
  • To investigate the influence of maternal pregnancy conditions on neonatal metabolic programming.

Main Methods:

  • Collected anthropometric and biochemical data from 162 mother/newborn pairs at birth and 6 months.
  • Measured plasma glucose, insulin, total cholesterol, and triglycerides.
  • Statistically defined two classes of mothers/babies for comparative analysis.

Main Results:

  • Newborns exhibited normal anthropometric patterns despite maternal overweight status.
  • Average glycemic profiles were within expected ranges at birth and 6 months.
  • Triglyceride levels in newborns were higher than expected values at both time points.

Conclusions:

  • Maternal pregnancy conditions, particularly overweight status, may influence neonatal metabolic programming.
  • While glycemic control appeared adequate, elevated triglycerides suggest potential lipid metabolism alterations.
  • Further research is needed to elucidate the long-term metabolic implications for these infants.

Keywords:
glycemic indexlipidsmetabolic syndrome Xmetabolismnewborn

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