Educational Case: Burkitt Lymphoma

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Updated: Aug 18, 2026

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines
06:38

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines

Published on: November 8, 2011

Caitlin J Alexander1, Laura M Wake1

  • 1Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.

Academic Pathology
|December 5, 2019
PubMed

Keywords:
Burkitt lymphomahematopathologylymph nodeslymphomaorgan system pathologypathology competenciespediatricwhite cell disorders

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...