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Acute Stress Increases Intraocular Pressure in Nonhuman Primates
Daniel C Turner1, Michelle Miranda2, Jeffrey S Morris2
1Department of Vision Sciences, School of Optometry, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Ophthalmology. Glaucoma
|December 5, 2019
Summary
Stressful events cause a rapid, significant increase in intraocular pressure (IOP) in nonhuman primates. This IOP elevation returns to baseline shortly after the stressful event concludes.
Area of Science:
- Ophthalmology
- Physiology
- Animal Models
Background:
- Intraocular pressure (IOP) is a critical factor in ocular health.
- Understanding IOP fluctuations during stress is vital for animal welfare and research.
Purpose of the Study:
- To quantify the change and time course of intraocular pressure (IOP) during stressful activity.
- To investigate physiological responses to a common anesthetic induction procedure in nonhuman primates.
Main Methods:
- Bilateral IOP and aortic blood pressure (BP) were continuously recorded in three nonhuman primates.
- Data were averaged before, during, and after anesthetic induction, including a cage squeeze and injection.
- Experiments were repeated four times per animal.
Main Results:
- Intraocular pressure (IOP), mean arterial pressure (MAP), and heart rate (HR) increased significantly (p<0.05) by 27%, 38%, and 34%, respectively.
- IOP rose approximately 10% within 10 seconds of anticipated stress and peaked within a minute.
- IOP returned to below baseline levels within one minute post-induction.
Conclusions:
- Intraocular pressure (IOP) increases rapidly and significantly in response to stressful situations in nonhuman primates.
- These findings highlight the physiological impact of stress on ocular parameters in animal models.