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Microfabrication of Chip-sized Scaffolds for Three-dimensional Cell cultivation
Published on: May 12, 2008
Microfluidic Printing of Three-Dimensional Graphene Electroactive Microfibrous Scaffolds.
Huaibin Qing1, Yuan Ji, Wenfang Li
1Guangdong Key Laboratory for Technology and Application of Metal Toughening , Guangdong Institute of Materials and Processing , Guangzhou 510650 , P.R.China.
ACS Applied Materials & Interfaces
|December 5, 2019
Summary
Microfluidic 3D printing creates tunable 3D graphene scaffolds. These conductive, biocompatible materials show promise for tissue regeneration and drug screening.
Area of Science:
- Materials Science
- Biotechnology
- Nanotechnology
Background:
- Graphene materials offer excellent conductivity, mechanical strength, and biocompatibility.
- Fabricating 3D graphene fibrous scaffolds remains a significant challenge despite advancements in micro/nano scaffold fabrication.
Purpose of the Study:
- To develop a novel method for fabricating 3D graphene oxide (GO) microfibrous scaffolds.
- To investigate the structural, mechanical, electrical, and biological properties of the fabricated scaffolds.
Main Methods:
- Utilized microfluidic 3D printing technology (M3DP) by integrating microfluidic spinning with a programmable 3D printing system.
- Fabricated 3D GO microfibrous scaffolds with adjustable fiber dimensions and structure.
- Converted GO scaffolds to conductive reduced graphene oxide (rGO) scaffolds via hydrothermal reduction.
Main Results:
- Demonstrated successful fabrication of 3D graphene microfibrous scaffolds with tunable structures.
- Showcased controllable mechanical properties, good electrical conductivity, and excellent biocompatibility.
- Observed oriented adhesion and proliferation of SH-SY5Y cells on the rGO scaffolds.
Conclusions:
- Microfluidic 3D printing technology (M3DP) is a powerful tool for creating 3D graphene microfibrous scaffolds.
- The fabricated scaffolds are suitable for electroactive tissue regeneration and drug-screening applications.
