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OPCs on a Diet: A Youthful Serving of Remyelination
Charles W White1, Karishma Pratt1, Saul A Villeda2
1Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA; Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco, San Francisco, CA, USA.
Cell Metabolism
|December 5, 2019
Abstract:
Remyelination declines in the aging central nervous system due to oligodendrocyte precursor cell (OPC) dysfunction. In the latest issue of Cell Stem Cell, Neumann et al. (2019) demonstrate that aged OPCs are amenable to functional rejuvenation by systemic interventions involving alternate-day fasting or treatment with the fasting mimetic metformin.