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Systemic Immune Profile in Patients With CRSwNP
Rafaela Veloso-Teles1,2,3, Rui Cerejeira1,2,3, Rosa Roque-Farinha1
1Faculty of Health Sciences, 70987University of Beira Interior, Covilhã, Portugal.
Ear, Nose, & Throat Journal
|December 6, 2019
Summary
Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) show distinct peripheral immune cell and immunoglobulin G subclass profiles. This suggests a unique systemic immune signature in CRSwNP.
Area of Science:
- Immunology
- Otolaryngology
- Respiratory Medicine
Background:
- The immune pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) is not fully understood.
- Investigating systemic immune differences may elucidate CRSwNP pathophysiology.
Purpose of the Study:
- To compare humoral immunity and white blood cell (WBC) counts in CRSwNP patients versus controls.
- To identify potential systemic immune markers associated with CRSwNP.
Main Methods:
- A prospective case-control study involving 37 CRSwNP patients and 34 controls.
- Evaluated clinical data, CT scans, spirometry, and serum immunological parameters including leukocyte differential counts and immunoglobulin (Ig) classes and IgG subclasses.
- Statistical analysis performed using SPSS v.23.
Main Results:
- CRSwNP patients exhibited higher relative eosinophil and basophil counts, and lower relative neutrophil counts compared to controls.
- Significantly elevated serum IgG1 levels were observed in CRSwNP patients.
- Lower serum levels of IgG2 and IgG3 were found in CRSwNP patients, while other Ig levels and deficiencies did not differ.
Conclusions:
- CRSwNP is associated with a unique peripheral leukocyte differential count and a systemic shift towards IgG1.
- These systemic immune alterations mirror findings in nasal polyp tissue, suggesting a consistent immune profile in CRSwNP.
