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MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method
Published on: October 7, 2025
Nanotechnology intervention of the microbiome for cancer therapy
Wantong Song1, Aaron C Anselmo2, Leaf Huang3,4
1Key Laboratory of Polymer Ecomaterials, Jilin Biomedical Polymers Engineering Laboratory, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, People's Republic of China.
Abstract:
The microbiome is emerging as a key player and driver of cancer. Traditional modalities to manipulate the microbiome (for example, antibiotics, probiotics and microbiota transplants) have been shown to improve efficacy of cancer therapies in some cases, but issues such as collateral damage to the commensal microbiota and consistency of these approaches motivates efforts towards developing new technologies specifically designed for the microbiome-cancer interface. Considering the success of nanotechnology in transforming cancer diagnostics and treatment, nanotechnologies capable of manipulating interactions that occur across microscopic and molecular length scales in the microbiome and the tumour microenvironment have the potential to provide innovative strategies for cancer treatment. As such, opportunities at the intersection of nanotechnology, the microbiome and cancer are massive. In this Review, we highlight key opportunistic areas for applying nanotechnologies towards manipulating the microbiome for the treatment of cancer, give an overview of seminal work and discuss future challenges and our perspective on this emerging area.
Insights
Nanotechnology offers innovative strategies for cancer treatment by targeting the microbiome. This review explores opportunities at the intersection of nanotechnology, the microbiome, and cancer therapy.
Area of Science:
- Oncology
- Microbiology
- Nanotechnology
Background:
- The microbiome significantly influences cancer development and progression.
- Current microbiome manipulation methods (antibiotics, probiotics, transplants) have limitations like collateral damage and inconsistency.
- There is a need for novel technologies specifically designed for the microbiome-cancer interface.
Purpose of the Study:
- To highlight opportunistic areas for applying nanotechnologies to manipulate the microbiome for cancer treatment.
- To provide an overview of seminal work in this emerging field.
- To discuss future challenges and perspectives.
Main Methods:
- Review of existing literature on nanotechnology, microbiome, and cancer.
- Identification of key areas where nanotechnologies can interface with the microbiome and tumor microenvironment.
- Analysis of the potential of nanotechnologies for cancer therapy.
Main Results:
- Nanotechnologies present significant opportunities for innovative cancer treatment strategies.
- Targeting the microbiome with nanotech can overcome limitations of traditional methods.
- The intersection of nanotechnology, microbiome, and cancer offers vast potential.
Conclusions:
- Nanotechnology holds immense promise for developing targeted cancer therapies by modulating the microbiome.
- Further research and development are crucial to overcome challenges and realize the full potential of this interdisciplinary field.
- This emerging area offers a paradigm shift in cancer treatment approaches.
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