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Updated: Jan 2, 2026
Laboratory Techniques Used to Maintain and Differentiate Biotypes of Vibrio cholerae Clinical and Environmental Isolates
Published on: May 30, 2017
A hybrid polymer to target blood group dependence of cholera toxin
Diksha Haksar1, Linda Quarles van Ufford, Roland J Pieters
1Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, P.O.Box 80082, 3508 TB Utrecht, The Netherlands. r.j.pieters@uu.nl.
Abstract:
Cholera is a potentially fatal bacterial infection caused by the cholera toxin (CT), an AB5 toxin secreted by Vibrio cholera. GM1 has long been known as the receptor of the cholera toxin in the intestine. However, increasing evidence is pointing towards the role of fucosylated conjugates as additional attachment options of the toxin. In the present paper we have synthesized a polymeric hybrid which can inhibit both modes of attachment.
