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Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
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Current Research and New Perspectives in Antifungal Drug Development

Iulian Oltu1, Liliana Cepoi2, Valeriu Rudic2

  • 1Hospital of Dermatology and Communicable Diseases, Chisinau, Republic of Moldova.

Advances in Experimental Medicine and Biology
|December 6, 2019
PubMed

Insights

Fungal infections are increasing due to immunosuppression. This review highlights new natural antifungal remedies and strategies for developing effective antifungal drugs with fewer side effects.

Area of Science:

  • Biomedicine
  • Pharmaceutics
  • Infectious Diseases

Background:

  • Rising incidence of fungal infections in immunocompromised individuals.
  • Growing challenge of antifungal resistance.
  • Need for novel antifungal agents with improved safety profiles.

Purpose of the Study:

  • To review recent advancements in antifungal drug development.
  • To focus on natural antifungal remedies.
  • To identify compounds with efficacy against fungal pathogens and minimal host toxicity.

Main Methods:

  • Literature review of recent achievements in antifungal drug development.
  • Focus on natural product research for antifungal discovery.
  • Analysis of studies reporting efficacy and safety of novel antifungal agents.

Main Results:

  • Overview of current antifungal drug development landscape.
  • Identification of promising natural compounds as antifungal agents.
  • Emphasis on agents with low adverse effects on the host organism.

Conclusions:

  • Natural remedies offer a promising avenue for new antifungal drug discovery.
  • Continued research is crucial to combat rising fungal infections and resistance.
  • Development of effective and safe antifungal treatments remains a priority.
Keywords:
Drug resistanceNatural antifungalsOxidative stressPathogenic fungiSpirulina extracts

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