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Clinical And Bacteriological Impact Of Clarithromycin In Streptococcal Pharyngitis: Findings From A Meta-Analysis Of
1Department of Medical Microbiology and Infectious Disease, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Drug Design, Development and Therapy
|December 6, 2019
Summary
Clarithromycin shows similar clinical cure rates for Group A beta-hemolytic Streptococci (GABHS) pharyngitis compared to other antibiotics. This study found higher bacteriological cure rates and good tolerability for clarithromycin in treating GABHS infections.
Area of Science:
- Infectious Diseases
- Bacteriology
- Pharmacology
Background:
- Group A beta-hemolytic Streptococci (GABHS) pharyngitis is a significant bacterial upper respiratory tract infection (URTI).
- Previous reviews suggest clarithromycin is effective and safe for pediatric URTIs and adult GABHS pharyngitis.
- This study adds a meta-analysis of comparative trials to the evidence base for clarithromycin in URTIs.
Purpose of the Study:
- To evaluate the efficacy and safety of clarithromycin for treating GABHS pharyngitis.
- To augment existing evidence through a meta-analysis of comparative outpatient trials.
Main Methods:
- A meta-analysis was conducted on five internal outpatient trials.
- Clarithromycin treatment outcomes were compared against penicillin VK and erythromycin.
Main Results:
- Clinical cure or improvement rates were comparable across all treatment groups.
- Clarithromycin demonstrated numerically higher rates of bacteriological cure.
- Adverse events were infrequent and generally mild, indicating good tolerability.
Conclusions:
- Clarithromycin is a viable, effective, and well-tolerated treatment for GABHS pharyngitis.
- It is a suitable option for patients who do not respond to or cannot tolerate other treatments.
- Despite not being a first-line agent in most guidelines, its efficacy is supported by this meta-analysis.
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